Prilocaine
General
- Type: Local anesthetics
- Dosage Forms:
- Common Trade Names:
Maximum Doses of Anesthetic Agents
Agent | Without Epinephrine | With Epinephrine | Duration | Notes |
Lidocaine | 5 mg/kg (max 300mg) | 7 mg/kg (max 500mg) | 30-90 min |
|
Mepivicaine | 7 mg/kg | 8 mg/kg | ||
Bupivicaine | 2.5 mg/kg (max 175mg) | 3 mg/kg (max 225mg) | 6-8 hr |
|
Ropivacaine | 3 mg/kg | |||
Prilocaine | 6 mg/kg | |||
Tetracaine | 1 mg/kg | 1.5 mg/kg | 3hrs (10hrs with epi) | |
Procaine | 7 mg/kg | 10 mg/kg | 30min (90min with epi) |
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating: B
- Lactation: Unknown
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- Methemoglobinemia
Adverse Reactions
Serious
- Local anesthetic systemic toxicity
- Confusion, disorientation
- Anaphylaxis
- Seizures
- Status asthmaticus
Common
- Anxiety, restlessness
- Dizziness
- Twitching, shivering
- Edema
Pharmacology
- Half-life: 10-150 min
- Metabolism: hepatic and renal
- Excretion: urinary
- Mechanism of Action: Local anesthetic; prevents generation/conduction of nerve impulses by reducing sodium permeability and increasing action potential threshold