Pregabalin

Administration

  • Type: GABA analog, analgesic
  • Dosage Forms:
  • Routes of Administration: oral
  • Common Trade Names: Lyrica

Adult Dosing

  • 50-200mg PO TID

Pediatric Dosing

Safety/efficacy not established

Special Populations

  • Pregnancy Rating: C (though fetal risk has been demonstrated)
  • Lactation risk: Infant risk has been demonstrated
  • Renal dosing: reduce dose per manufacturer/FDA guidelines
  • Hepatic dosing:

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Angioedema, hypersensitivity reaction
  • Jaundice
  • Elevated creatine kinase level
  • Suicidal thoughts

Common

  • Constipation, xerostomia, weight gain
  • Peripheral edema
  • Dizziness, ataxia, somnolence, blurred vision, headache
  • Nasopharyngitis
  • Disturbance in thinking, euphoria

Pharmacology

  • Half-life: 6.3h
  • Metabolism:
  • Excretion: Mostly renal

Mechanism of Action

  • GABA-analog, exact mechanism of analgesic effect poorly understood

Comments

See Also

References

Authors:

Claire