Pantoprazole

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General

  • Type: Proton-pump inhibitor
  • Dosage Forms:
  • Common Trade Names: Protonix, Somac, Forppi, Pantoloc, Pantozol, Pantomed, Zurcal, Zentro, Pan, Controloc, Tecta

Adult Dosing

Upper gastrointestinal bleeding

  • 80mg x 1; then 8mg/hr

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • anaphylaxis
  • SJS/TEN
  • Renal impairment
  • pancreatitis
  • hepatic impairment

Common

  • Headache
  • abdominal pain
  • nausea/vomiting/diarrhea
  • AST/ALT elevation

Pharmacology

  • Half-life: 1 hour
  • Metabolism: Hepatic - CYP450
  • Excretion: Urine/Feces
  • Mechanism of Action: inhibits gastric parietal cell H+/K+ ATPase

See Also

References