Pantoprazole

General

  • Type: Proton-pump inhibitor
  • Dosage Forms:
  • Common Trade Names: Protonix, Somac, Forppi, Pantoloc, Pantozol, Pantomed, Zurcal, Zentro, Pan, Controloc, Tecta

Adult Dosing

Upper gastrointestinal bleeding

  • 80mg IV x 1; then 8mg/hr OR 80mg IV BID

GERD, Peptic ulcer disease, Esophagitis

  • 40mg IV or PO daily

Pediatric Dosing

  • <5yo: safety/efficacy not established
  • >5yo
    • 15 kg to <40 kg: 20 mg PO qDay
    • 40 kg or greater: 40 mg PO qDay

Special Populations[1]

  • Pregnancy Rating: B
  • Lactation:
    • Pantoprazole is present in breast milk
  • Renal Dosing
    • Adult
      • No adjustment necessary
    • Pediatric
      • Not defined
  • Hepatic Dosing
    • Adult
      • No adjustment necessary
    • Pediatric
      • Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • anaphylaxis
  • SJS/TEN
  • Renal impairment
  • pancreatitis
  • hepatic impairment

Common

  • Headache
  • abdominal pain
  • nausea/vomiting/diarrhea
  • AST/ALT elevation

Pharmacology

  • Half-life: 1 hour
  • Metabolism: Hepatic - CYP450
  • Excretion: Urine/Feces
  • Mechanism of Action: inhibits gastric parietal cell H+/K+ ATPase

See Also

References

  1. Pantoprazole: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.