Oxycodone

General

  • Type: opioid
  • Dosage Forms: PO
  • Common Trade Names: Roxicodone, Oxycontin

Adult Dosing

Opioid-Naive Patients

  • Start: 5-15mg PO q4-6h PRN
    • Use lowest effective dose and shortest effective duration (NOT a first-line treatment)
    • Use caution in older patients

Opioid-Experienced Patients

  • Individualize based on current opioid intake q4-6h PRN
    • Use caution in older patients
    • See Opioid Dosing Chart for dose conversion information
    • Taper dose by 25-50% q2-4 days to discontinue if long-term use

Pediatric Dosing

General Pain

  • 0.05-0.15mg/kg PO q4-6h PRN
  • Max: 5mg/dose

Special Populations

  • Pregnancy Rating: C
  • Lactation Risk Categories: possibly unsafe
  • Renal Dosing
    • Adult: CrCl < 60: decrease starting dose
    • Pediatric: CrCl 10-50: decrease starting dose 25%, CrCL < 10: decrease dose 50%
  • Hepatic Dosing
    • Adult: not defined
    • Pediatric: not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Respiratory Depression
  • Apnea
  • syncope
  • bradycardia
  • Seizures
  • anaphylaxis

Common

  • Nausea
  • Rash
  • Headache
  • Fatigue
  • xerostomia
  • constipation
  • Tremor
  • transaminitis

Pharmacology

  • Half-life: 3.5-4 hour
  • Metabolism: Liver
  • Excretion: urine
  • Mechanism of Action:binds to various opioid receptors