Oxycodone

General

• Type: Opioid
• Dosage Forms: PO
• Common Trade Names: Roxicodone, Oxycontin
• Commonly combined with acetaminophen as Percocet

Adult Dosing

Opioid-Naive Patients

• Start: 5-15mg PO q4-6h PRN
  • Use lowest effective dose and shortest effective duration (NOT a first-line treatment)
  • Use caution in older patients

Opioid-Experienced Patients

• Individualize based on current opioid intake q4-6h PRN
  • Use caution in older patients
  • See Opioid Dosing Chart for dose conversion information
  • Taper dose by 25-50% q2-4 days to discontinue if long-term use

Pediatric Dosing

General Pain

• 0.05-0.15mg/kg PO q4-6h PRN
• Max: 5mg/dose

Special Populations

• Pregnancy Rating: C
• Lactation Risk Categories: possibly unsafe
• Renal Dosing
  • Adult: CrCl < 60: decrease starting dose
  • Pediatric: CrCl 10-50: decrease starting dose 25%, CrCL < 10: decrease dose 50%
• Hepatic Dosing
  • Adult: not defined
  • Pediatric: not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Respiratory Depression
• Apnea
• Syncope
• Bradycardia
• Seizures
• Anaphylaxis

Common

• Nausea
• Rash
• Headache
• Fatigue
• xerostomia
• constipation
• Tremor
• transaminitis

Pharmacology

• Half-life: 3.5-4 hour
• Metabolism: Liver
• Excretion: urine
• Mechanism of Action:binds to various opioid receptors