Oxybutynin

Administration

  • Type: Antispasmodic, urinary
  • Dosage Forms: 5mg
  • Routes of Administration: Oral
  • Common Trade Names: Oxybutynin chloride

Adult Dosing

  • 5mg 2-3 times daily, maximum 5mg 4 times daily

Pediatric Dosing

  • > 5 years and adolescent
    • 5mg twice daily, maximum 5mg 3 times daily

Geriatric Dosing

  • 2.5mg 2-3 times daily, increase cautiously

Special Populations

Renal Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug
  • Risk of narrow-angle glaucoma
  • Risk of urinary retention
  • Risk of gastric retention or severely decreased gastric motility

Adverse Reactions

Serious

  • Arrhythmia (sinus)
  • Hypotension
  • Hypertension

Common

  • Dizziness
  • Drowsiness
  • Xerostomia (dose-related)
  • Constipation
  • Nausea
  • Headache
  • Nervousness
  • Insomnia
  • Urinary hesitancy
  • Urinary retention
  • Urinary tract infection
  • Blurred vision

Pharmacology

  • Half-life: 2-3 h
  • Metabolism: Liver
  • Excretion: Urine

Mechanism of Action

  • Direct antispasmodic effect on smooth muscle
  • Inhibit action of acetylcholine on smooth muscle; decreased frequency and urgent

Comments

See Also

References