Oxazepam

Administration

  • Type: Benzodiazepine
  • Dosage Forms:
  • Routes of Administration: Oral
  • Common Trade Names: Serax

Adult Dosing

  • ETOH withdrawal: 15-30mg PO 3-4 times per day
  • Insomnia: 15mg PO at bedtime

Pediatric Dosing

Safety/efficacy not established in children <12yo

  • >12yo, ETOH withdrawal: 15-30mg PO 3-4 times per day

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: Infant risk cannot be ruled out
  • Renal dosing: no adjustment
  • Hepatic dosing: clearance may be reduced in severe liver disease

Contraindications

  • Allergy to class/drug
  • Psychosis

Adverse Reactions

Serious

  • Withdrawal syndrome

Common

  • Dizziness, vertigo
  • Somnolence
  • Headache

Pharmacology

  • Half-life: 5.7-10.9h
  • Metabolism:
  • Excretion: Renal

Mechanism of Action

  • Long-acting benzodiazepine, GABA-receptor agonist

Comments

See Also

References

Authors:

Claire