Naproxen

Administration

  • Type: NSAID
  • Dosage Forms:
  • Routes of Administration: PO
  • Common Trade Names: Aleve

Adult Dosing

  • 500mg PO BID OR 250mg q6-8h

Pediatric Dosing

  • 5mg/kg BID

Special Populations

Renal Dosing

  • Adult: Not recommended if CrCl <30
  • Pediatric:

Hepatic Dosing

  • Adult: use lowest effective dose
  • Pediatric:

Contraindications

  • Allergy to class/drug
  • peri-CABG

Adverse Reactions

Serious

  • GI bleed, gastric ulcer
  • Nephrotoxicity
  • Angioedema
  • Bronchospasm
  • CHF, pulmonary edema
  • Thrombocytopenia, aplastic anemia, hemolytic anemia, agranulocytosis
  • Vasculitis
  • SJS/TEN
  • Hepatotoxicity (hepatitis, liver failure)
  • Aseptic meningitis, seizure

Common

  • Nausea, heartburn, constipation
  • Edema
  • Ecchymosis
  • Headache
  • Ototoxicity

Pharmacology

  • Half-life: 12-17 hours
  • Metabolism:
  • Excretion: Renal

Mechanism of Action

  • NSAID

Comments

See Also

References