Mupirocin

General

  • Type: Antibacterials, Topical
  • Dosage Forms: 2% cream, ointment
  • Routes of Administration: topical
  • Common Trade Names: Bactroban, Centany

Adult Dosing

Impetigo

  • apply ointment TID x 7-14 days

Skin infections, bacterial

  • apply cream TID x 10 days

Pediatric Dosing

Impetigo (2mos and older)

  • apply ointment TID x 7-14 days

Skin infections, bacterial (3mos and older)

  • apply cream TID x 10 days

Special Populations

Renal Dosing

  • Adult: NA
  • Pediatric: NA

Hepatic Dosing

  • Adult: NA
  • Pediatric: NA

Contraindications

  • Allergy to class/drug
  • large open wounds
  • caution if renal impairment, mod-severe

Adverse Reactions

Serious

  • hypersensitivity run
  • anaphylaxis
  • C. difficile-assoc diarrhea
  • superinfection (prolonged use)

Common

  • nausea
  • burning
  • headache
  • pruritus
  • pain
  • stinging

Pharmacology

  • Half-life: 20-40 min
  • Metabolism: liver; CYP450; <0.3% systemic absorption
  • Excretion: urine <3%
  • Mechanism of Action: bacteriostatic or bactericidal, depending on susceptibility and concentration; reversibly binds to isoleucyl-tRNA synthetase, inhibiting protein synthesis (monoxycarbolic acid)

See Also

References