Metoprolol

General

• Type: Beta blockers
• Dosage Forms: Tablet: 25 mg, 37.5 mg, 50 mg, 75mg, 100 mg. IV: variable
• Common Trade Names: Lopressor

Adult Dosing

Hypertension

• 50-200 mg PO bid

CHF

• 12.5-100 mg PO bid

Migraine prophylaxis

• 25-100 mg PO bid

Special Populations

• Pregnancy Rating:
• Lactation:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug
• Sinus bradycardia
• AV blocks
• decompensated acute CHF
• cardiogenic shock
• hypotension

Adverse Reactions

Serious

• CHF
• bradycardia
• AV block
• bronchospasm

Common

• fatigue
• dizziness
• depression
• dyspnea

Pharmacology

• Half-life: 3-7 hours
• Metabolism: Liver
• Excretion: Renal
• Mechanism of Action: Selective Beta-1 adrenergic receptor antagonist

See Also

• Antiarrhythmics
• Calcium Channel Blocker Toxicity
• Atrial Fibrillation with RVR

Authors:

Eric Lee, Michael Holtz, Neil Young, Daniel Ostermayer, Ross Donaldson