Methohexital
General
- Type: Sedative agents
- Dosage Forms:
- Common Trade Names: Brevital
Adult Dosing
- Dose 1-1.5mg/kg
Pediatric Dosing
- >1mo: 6.6-10 mg/kg IM administered as a 5% (50 mg/mL) solution
Special Populations
- Pregnancy Rating: B
- Lactation risk: Excreted in breastmilk
- Renal Dosing: Caution
- Hepatic Dosing: Caution
Contraindications
- Allergy to class/drug
- Porphyria
- Relative: cardiovascular disease, hypotension, respiratory disease
- Caution if: severe anemia, extreme obesity, debilitated patients, renal/hepatic/endocrine/circulatory dysfunction, obstructive pulmonary disease, severe HTN, status asthmaticus
Adverse Reactions
Serious
- Laryngospasm
- Apnea, respiratory depression
- Hypotension
- Myocardial depression
- Seizures
Common
- Hiccups, muscle twitching, coughing
- Shivering
- Salivation
- Emergence reaction
- Anxiety, restlessness
- Headache
- Nausea/vomiting, abdominal pain
- Erythema, pruritus, urticaria
- Rhinitis
- Thrombophlebitis
- Injection site pain
Pharmacology
- Half-life: 3-6h
- Metabolism: Hepatic
- Excretion: Urine
- Mechanism of Action: ultra short acting barbituate
- Onset < 1 minute; Duration 10 minutes
Comments
- No analgesic effect