Lansoprazole

Administration

  • Type: PPI
  • Dosage Forms: Capsule and Tablet; 15mg & 30mg
  • Routes of Administration: oral, IV
  • Common Trade Names: Prevacid

Adult Dosing

  • 15-30mg daily

Pediatric Dosing

  • Age 1-11 years, weight <30kg: 15mg daily
  • Age >1 year, weight >30kg: 15-30mg daily

Special Populations

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • C. difficile diarrhea
  • SJS/TEN
  • Rhabdomyolysis
  • Interstitial nephritis
  • Fracture
  • Hypomagnesemia

Common

  • Abdominal pain, diarrhea, nausea, constipation
  • Headache

Pharmacology

  • Half-life: 1.5-3 hours
  • Metabolism: Hepatic
  • Excretion: Mostly biliary/fecal

Mechanism of Action

  • Inhibits gastric parietal cell H+/K+ proton pump, leading to decreased gastric acid secretion

Comments

See Also

References

Authors:

Claire