Labetalol

(Redirected from Labetolol)

General

Adult Dosing

  • Bolus dosing
    • 20mg IV followed by 40-80mg q10min up to total of 300mg
  • Infusion dosing
    • 0.5-2mg/min

Intracranial hemorrhage

  • Start with labetalol 20mg over 1-2 minutes
    • Then, 20mg q3-5 mins until target blood pressure is achieved
    • Then, start an infusion of 1-8mg/min

Pediatric Dosing

Special Populations

  • Pregnancy Rating: C
  • Lactation: Compatible with breastfeeding
  • Renal Dosing
    • Adult
      • No renal dosing adjustments necessary. Drug not removed with hemodialysis
    • Pediatric
      • No renal dosing adjustments necessary. Drug not removed with hemodialysis
  • Hepatic Dosing
    • Adult
      • May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution.
    • Pediatric
      • May need reduced dosing given decreased metabolism and increased oral bioavailability with hepatic impairment however no specific dosing adjustments in manufacturer labeling. Use caution.

Indications

  • hypertension in setting of myocardial ischemia
  • hypertension in setting of neurologic injury
  • hypertension in setting of preeclampsia/eclampsia

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Orthostatic hypotension

Pharmacology

  • Half-life: 5-8hrs
  • Metabolism: Hepatic via conjugation
  • Excretion: Renal 55-60%
  • Mechanism of Action:
    • Class II - Nonselective β-blocker
    • α1-blocker
  • Onset of action = 2-5min (IV)
  • Duration of action = 2-4hr (IV)

See Also

References


Labetalol: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.