Labetalol

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General

Adult Dosing

  • Bolus dosing
    • 20mg IV followed by 40-80mg q10min up to total of 300mg
  • Infusion dosing
    • 0.5-2mg/min

Pediatric Dosing

Special Populations

  • Pregnancy Rating: C
  • Lactation: Compatible with breastfeeding
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Indications

  • hypertension in setting of myocardial ischemia
  • hypertension in setting of neurologic injury
  • hypertension in setting of preeclampsia/eclampsia

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • Orthostatic hypotension

Pharmacology

  • Half-life: 5-8hrs
  • Metabolism: Hepatic via conjugation
  • Excretion: Renal 55-60%
  • Mechanism of Action:
    • Class II - Nonselective β-blocker
    • α1-blocker
  • Onset of action = 2-5min (IV)
  • Duration of action = 2-4hr (IV)

See Also

References