Ibutilide

General

Adult Dosing

  • Loading dose = 1mg IV in 50mL D5W over 10min (wt>60kg)
  • Loading dose = 0.01mg/kg IV in 50mL D5W over 10min (wt<60kg)
  • Dose may be repeated 10min after completion of 1st dose

Pediatric Dosing

Special Populations

Indications

  • Rapid conversion of recent-onset A-fib/flutter to NSR

Contraindications

  • Allergy to class/drug

Adverse Reactions

  • QT prolongation, V-tach, torsades
  • Observe for 4hr after infusion

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action: Class III - Prolongs AP and refractory period

Kinetics

  • Onset of action = 20-30min
  • Duration of action = 24hr

Comments

See Also

References