Hydroxyurea

Administration

  • Type: Antineoplastic
  • Dosage Forms:
  • Routes of Administration: oral
  • Common Trade Names:

Adult Dosing

Pediatric Dosing

  • Off label for sickle cell, 10-35mg/kg/day

Special Populations

Pregnancy Rating

  • D

Lactation risk

  • Infant risk cannot be ruledout

Renal Dosing

  • Reduce dose if CrCl <60. Administer after dialysis on HD days

Hepatic Dosing

  • Adult:
  • Pediatric:

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Skin ulceration, skin cancer, gangrene
  • Genetic mutations w/longterm use
  • Parvovirus infection

Common

Pharmacology

  • Half-life: 2-4.5 hours
  • Metabolism: Hepatic 60%
  • Excretion: Renal(40%)

Mechanism of Action

  • Inhibits DNA synthesis by acting as a ribonucleotide reductase inhibitor

Comments

See Also

References

Authors:

Claire