Hydrocodone

General

• Type: Opioid
• Dosage Forms: PO
• Common Trade Names: Zohydro, Hysingla
• Commonly combined with acetaminophen as Norco and Vicodin

Adult Dosing

General

• For Pain, severe chronic: Individualize dose PO q12h; start 10mg PO q12h, may increase by 10mg PO q12h q3-7 days. Titrate slowly in elderly patients.

Pediatric Dosing

• Currently not recommended

Special Populations

• Pregnancy Rating: C
• Lactation Risk Categories: possibly unsafe
• Renal Dosing
  • Adult: none
  • Pediatric: none
• Hepatic Dosing
  • Adult: not defined
  • Pediatric: not defined

Contraindications

• Allergy to class/drug
• labor and delivery
• GI obstruction
• paralytic ileus
• acute asthma exacerbation

Adverse Reactions

Serious

• respiratory depression
• apnea
• hypotension, severe
• paralytic ileus
• bradycardia
• anaphylaxis

Common

• Constipation
• nausea
• fatigue
• vomiting
• xerostomia
• headache
• URI
• tremor

Pharmacology

• Half-life: 8 hour
• Metabolism: Liver
• Excretion: urine
• Mechanism of Action: bind to various opioid receptors