Hirudins

Background

  • Direct thrombin inhibitors

Drugs

  • Hirudin
  • Lepirudin
  • Argatroban

Indications

Complications

  • Bleeding
    • Majority of bleeding events occur at invasive sites
    • No antidote available
    • Minor bleeding
      • Stop infusion
    • Major bleeding
      • Give FFP or PCC

Pharmacology

  • Half-life is ~2hr

References