Glucarpidase

Administration

  • Dosage Forms: 1000 units/vial
  • Routes of Administration: IV
  • Common Trade Names: Voraxaze

Adult Dosing

Pediatric Dosing

Special Populations

  • Pregnancy Rating: C; Benefits outweigh risks during pregnancy
  • Lactation risk: L3; Safety unknown

Renal Dosing

  • Adult: No adjustment
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: No adjustment
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 5.6 hr, 8.2 hr (Crcl < 30)
  • Metabolism: Unknown
  • Excretion: Unknown

Mechanism of Action

  • Hydrolyzes carboxyl-terminal glutamate, converting methotrexate to inactive metabolisms.

Comments

See Also

Methotrexate toxicity

References

Authors:

Jonathan Warren