Fomepizole

Administration

  • Type: Alcohol dehydrogenase inhibitor
  • Routes of Administration: Intravenous
  • Common Trade Names: Antizol

Adult Dosing

  • Loading: 15 mg/kg
  • Maintenance: 10 mg/kg every 12 hours

Pediatric Dosing

  • Loading: 15 mg/kg
  • Maintenance: 10 mg/kg every 12 hours

Special Populations

Hemodialysis Dosing

For patients undergoing hemodialysis for complications associated with toxic alcohol ingestion, dosing should be adjusted in consultation with a nephrologist.

Hepatic Dosing

Fomepizole is metabolized in the liver, specific dosing adjustments for hepatic impairment have not been developed.

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Bradycardia
  • Hypotension
  • Shock
  • Anemia
  • Disseminated intravascular coagulation (DIC)

Common

  • Headache
  • Nausea

Pharmacology

  • Half-life: Not calculated
  • Metabolism: Hepatic
  • Excretion: Urine

Mechanism of Action

Competitively inhibits alcohol dehydrogenase.

See Also

Toxic Alcohols

References

  1. Lexicomp