Flurazepam
Administration
- Type: Benzodiazepine
- Dosage Forms: CAP 15mg, 30mg
- Routes of Administration: Oral
- Common Trade Names: Dalmane
Adult Dosing
Insomnia, short term tx
- 15mg PO qhs
Pediatric Dosing
Safety/efficacy not established in pediatric patients
Special Populations
Pregnancy Rating
- Category C
- Consider alternatives in pregnancy
- Risk of neonatal withdrawal and floppy infant syndrome
Lactation risk
- Use alternative or consider short-acting benzodiazepines while breastfeeding
Renal Dosing
- Adult: No adjustment
- Pediatric: Not defined
Hepatic Dosing
- Adult: Not defined.
- Pediatric: Not defined
Contraindications
- Allergy to class/drug
- Pregnancy
- Avoid abrupt withdrawal with long-term use
Adverse Reactions
Serious
- Anaphylaxis
- Angioedema
- Complex sleep-related behavior
- Respiratory depression, tachycardia, hypotension, syncope
- Dependency, suicidality
- Seizures
Common
- Dizziness, drowsiness, ataxia, confusion, headache
- Disinhibition, irritability
- Dystonia, dysarthria
- Appetite change, menstrual irregulatrity
- Incontinence
- Rash
Pharmacology
- Half-life: 2-3h; 40-100h active metabolite
- Metabolism: Liver extensively; 3A4 partial substrate
- Excretion: Urine
Mechanism of Action
- Binds to benzodiazepine receptors to enhance GABA effects