Fidaxomicin

Administration

  • Type: Macrolide antibiotic
  • Dosage Forms:
  • Routes of Administration: PO
  • Common Trade Names:

Adult Dosing

  • C. diff diarrhea: 200mg PO BID x 10d

Pediatric Dosing

Safety/efficacy not established

Special Populations

Pregnancy Rating

  • Category B

Lactation risk

  • Infant risk cannot be ruled out

Renal Dosing

  • No adjustment

Hepatic Dosing

  • Not established

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: ~12h
  • Metabolism: Intestinal
  • Excretion: Fecal

Mechanism of Action

  • Macrolide: inhibits RNA polymerases primarily against clostridia species

Comments

See Also

References

Authors:

Claire