Fenoldopam

Administration

  • Type: Antihypertensive, Dopamine agonist
  • Dosage Forms: 10mg/mL (1 mL), 20mg/2 mL (2 mL)
  • Routes of Administration: Intravenous
  • Common Trade Names: Corlopam

Adult Dosing

  • Severe hypertension: Initial 0.01 to 0.3 mcg/kg/minute, increase incrementally 0.05 to 0.1 mcg/kg/minute q 15 minute until target blood pressure is reached (maximum dose recorded in the study was 1.6 mcg/kg/minute), limit for up to 48-hour use.

Pediatric Dosing

  • Severe hypertension: Initial 0.2 mcg/kg/minute; increase incrementally 0.3 to 0.5 mcg/kg/minute q 20 to 30 minutes (maximum 0.8 mcg/kg/minute), limit for 4-hour use

Special Populations

Renal Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug
  • Caution if:
    • sulfite hypersensitivity
    • asthma
    • glaucoma, intraocular HTN, elevated ICP
    • acute stroke
    • cardiac disease, arrythmias
    • hypokalemia
    • active bleeding
    • portal hypertension

Adverse Reactions

Serious

  • hypotension, severe
  • tachycardia
  • CHF, MI, angina
  • hypokalemia
  • leukocytosis

Common

  • headache, dizziness
  • flushing, diaphoresis, anxiety, tachycardia
  • hypotension
  • ST-T wave changes
  • nausea/vomiting, abdominal pain, diarrhea, constipation
  • injection site reaction
  • back pain
  • nasal congestion
  • IOP elevation

Pharmacology

  • Half-life: 5 min
  • Metabolism: Liver extensively; CYP450
  • Excretion: urine 90%, feces 10%

Mechanism of Action

  • stimulates dopamine D1-like and α-2 adrenergic receptors

Comments

See Also

References