Famciclovir

General

  • Type: DNA polymerase inhibitor
  • Dosage Forms: 125, 250, 500 PO
  • Common Trade Names: Famvir

Adult Dosing

HSV-1

  • 500mg PO TID

Pediatric Dosing

  • Unavailable

Special Populations

  • Pregnancy Rating: B
  • Lactation: Safety Unknown
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric
  • Famvir Pregnancy Registry: 1-888-669-6682

Contraindications

  • Allergy to class/drug
  • caution if renal impairment

Adverse Reactions

Serious

  • neutropenia
  • thrombocytopenia
  • skin reaction, severe
  • hallucinations
  • delirium

Common

  • headache
  • nausea
  • diarrhea
  • vomiting
  • fatigue
  • pruritus
  • neutropenia
  • abnormal LFTs
  • paresthesia
  • flatulence

Pharmacology

  • Half-life: 2-3h
  • Metabolism: liver, CYP450
  • Excretion: urine primarily, feces
  • Mechanism of Action: inhibits DNA polymerase, selectively inhibiting herpes viral DNA synthesis and replication

See Also

References