- Also known as Haxthausen disease
- Exposure to cold temperatures → inflammation and mild necrosis of subcutaneous fat tissue
- Infants are most susceptible due to higher percentage of saturated fatty acids in newborn fat tissue
- Erythematous, indurated, tender, firm plaques or nodules on areas exposed to cold
- Lesions develop 24-72 hours after exposure and resolve within 2 weeks
- Resolution may result in adipose fibrosis with cosmetic defects (especially if area is not protected from further cold exposure)
- Clinical diagnosis
- Reproduction of lesions approximately half a day after application of an ice cube to the volar forearm for 2 minutes may help with diagnosis
- Protect affected area from further cold exposure
- Otherwise, no specific treatment (lesions resolve spontaneously)
- Bolotin D, et al. Cold panniculitis following ice therapy for cardiac arrhythmia. Pediatr Dermatol. 2011 Mar-Apr;28(2):192-4.
- Quesada-Cortés A, et al. Cold panniculitis. Dermatol Clin. 2008 Oct;26(4):485-9
- Lipke MM, Cutlan JE, Smith AC. Cold panniculitis: delayed onset in an adult. Cutis. 2015 Jan;95(1):21-4.