Ceftaroline fosamil

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General

  • Type: 5th Generation Cephalosporin
  • Dosage Forms: injectable, powder for reconstitution
  • Dosage Strengths: 400mg/vial, 600mg/vial
  • Routes of Administration: IV
  • Common Trade Names: Teflaro

Adult Dosing

Community Acquired Pneumonia

  • 600mg IV q12h x5-7 days

Cellulitis

  • 600mg IV q12h x5-14 days

Renal Dosing

  • CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h

Hepatic Dosing

  • No adjustment

Pediatric Dosing

  • Currently no pediatric dosing for this drug.

Special Populations

  • Pregnancy Rating:B
  • Lactation: Safety Unknown
  • Renal Dosing
    • Adult: CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h
    • Pediatric: Drug not available for pediatrics
  • Hepatic Dosing
    • Adult: No Adjustment
    • Pediatric: NA

Contraindications

  • Allergy to class/drug (see also Cephalosporin Cross-reactivity)
  • Caution if hypersensitive to beta-lactams
  • Caution if recent antibiotic-associated colitis history

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 2.6 Hours
  • Metabolism: Hydrolysis; CYP450: none; prodrug converted to ceftaroline
  • Excretion: Urine primarily
  • Mechanism of Action: Bactericidal, inhibits cell wall mucopeptide synthesis

See Also

References