Bupropion toxicity

(Redirected from Bupropion Toxicity)

Background

  • Bupropion is a norepinephrine/dopamine reuptake inhibitor used for depression, ADHD, and smoking cessation
  • Toxicity occurs with ingestion of >450mg/d

Clinical Features

Differential Diagnosis

Seizure

Evaluation

Management

  • GI decontamination
    • Consider whole-bowel irrigation for sustained-release formulations
  • Seizure Treatment
  • Early vasopressor and ionotropic agents for hemodynamic instability (Bupropion depresses myocardial contractility)
  • Intralipid for refractory cases

Disposition

  • Consider discharge if asymptomatic after 8hr for regular-release ingestions

See Also

References

Authors:

Ross Donaldson