Antivenin

Administration

  • Type: Antivenom
  • Dosage Forms: IM, IV
  • Routes of Administration: IM/IV
  • Common Trade Names: Antivenin

Adult Dosing

  • Black widow spider bite
    • 2.5 mL IM/IV x1
      • Give skin or conjunctival test before use
      • May repeat dose x1
      • Prefer IV for severe cases

Pediatric Dosing

  • Black widow spider bite
    • <12 yo
      • 2.5 mL IM/IV x1
        • Give skin or conjunctival test before use
        • May repeat dose x1
    • >12 yo
      • 2.5 mL IM/IV x1
        • Give skin or conjunctival test before use
        • May repeat dose x1
        • Prefer IV for severe cases

Special Populations

  • Pregnancy Rating: C; Benefits outweight risks during pregnancy
  • Lactation risk: L3; Safety unknown

Renal Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Contraindications

  • Allergy to class/drug
  • Caution if hypersensitivity to horse serum
  • Caution if asthma

Adverse Reactions

Serious

Common

  • Injection site pain
  • Hypersensitivity reaction
  • Muscle cramps

Pharmacology

  • Half-life: <15 days
  • Metabolism: Unknown
  • Excretion: Unknown

Mechanism of Action

  • A equine serum globulin that binds to toxins

Comments

See Also

References

Authors:

Jonathan Warren