Angiotensin II

Administration

• Type: vasopressor
• Dosage Forms: Injection: 2.5 mg/mL and 5 mg/2 mL (2.5 mg/mL) in a vial
• Routes of Administration: IV
• Common Trade Names: GIAPREZA

Adult Dosing

Septic or Distributive Shock

• 20 nanograms (ng)/kg/min.
  • Titrate as frequently as every 5 minutes by increments of up to 15 ng/kg/min as needed.
    

During the first 3 hours, the maximum dose should not exceed 80 ng/kg/min.
Maintenance dose should not exceed 40 ng/kg/min

Special Populations

Pregnancy Rating

• unkown

Lactation risk

• unknown

Renal Dosing

None

Hepatic Dosing

None

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Thrombosis (13%)
  • DVT (4%)
• Thrombocytopenia (9%)
• Tachycardia (8.6%)
• Fungal infection (6.1%)

Pharmacology

• Half-life: ~1 minute
• Metabolism: broken down by proteins in blood, RBC's, major organs

Mechanism of Action

• Synthetic human angiotensin II which is a peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure
• Increases Aldosterone

Comments

• Patient's on ACEi may have increased response to Angiotensin II
• Patient's on ARB's may have decreased response to Angiotensin II

See Also

• Sepsis (Main)