Amyloidosis

Background

  • Accumulation of proteins (amyloid fibrils) in tissues
  • Heart and kidneys most commonly affected organs
  • Causes:
    • Primary amyloidosis, hereditary amyloidosis
    • Secondary (due to systemic inflammatory condition)
    • ESRD-associated (caused by β2-microglobulin amyloids, not filtered out by dialysis membranes))
    • Senile amyloidosis (causes cardiac amyloid)

Clinical Features

Differential Diagnosis

Evaluation

  • Evaluate for other causes of symptoms
  • Diagnosis via fat pad biopsy: apple-green birefringence with Congo red stain

Management

  • Varies depending on underlying etiology and organ systems involved

Disposition

See Also

External Links

References