Amiloride

Administration

  • Type: Potassium-sparing diuretic
  • Dosage Forms: tablet
  • Routes of Administration: Oral
  • Common Trade Names: Midamor

Adult Dosing

  • 5-20 mg PO daily

Pediatric Dosing

Not indicated in pediatric patients

Special Populations

  • Pregnancy Rating: B
  • Lactation risk:
  • Renal dosing:
    • Avoid if CrCl <50
    • CrCl 10-50: reduce dose by 50%
  • Hepatic dosing: no adjustment

Contraindications

  • Allergy to class/drug
  • Anuria, acute or chronic renal insufficiency, diabetic nephropathy
  • Hyperkalemia
  • Concomitant use of antikaliuretic agents, potassium supplementation/salt substitutes, or other potassium-sparing agents

Adverse Reactions

Serious

  • Hyperkalemia
  • Cardiac dysrhythmia, palpitations
  • Aplastic anemia, neutropenia
  • Encephalopathy
  • Raised intraocular pressure

Common

  • Nausea/vomiting, diarrhea, loss of appetite
  • Rash
  • Asthenia, muscle cramps
  • Cough, dyspnea
  • Dizziness
  • Headache

Pharmacology

  • Half-life: 6-9h
  • Metabolism: NOT hepatic
  • Excretion: Renal, fecal

Mechanism of Action

  • Potassium-sparing diuretic: inhibits epithelial sodium channel in distal renal tubule

Comments

See Also

References

Authors:

Claire, Matin Shah