Allergic transfusion reaction

Background

  • Occurs due to immune response to plasma proteins
  • Reaction severity not dose-related
  • Most frequently occur with platelet transfusions

Clinical Features

  • Symptoms range from urticaria/pruritus to bronchospasm, wheezing, anaphylaxis (rare)

Differential Diagnosis

Transfusion Reaction Types

Acute allergic reaction

Evaluation

Management

  • Stop transfusion until able to evaluate severity of allergic reaction
  • Give diphenhydramine
  • Restart transfusion if symptoms are mild

Disposition

See Also

External Links

References