African trypanosomiasis
Background
- AKA sleeping sickness
- Caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense
- Transmitted by the tsetse fly
Clinical Features
- Initial features
- Localized inflammatory reaction after tsetse fly bite
- Painless chancre 2-3 days later, lasts 2-3 weeks
- Systemic disease
- Intermittent Fever
- Malaise, wasting
- CNS involvement
- Behavioral changes
- Encephalitis
- Coma
- Death
- Other complications
- Hemolysis, anemia
- Pancarditis
- Meningoencephalitis
- Winterbottom's sign: posterior cervical LAD (Gambiense)
Differential Diagnosis
- Papules
- Insect bites
- Scabies
- Seabather's eruption
- Cercarial dermatitis (Swimmer's Itch)
- Macular
- Sub Q Swelling and Nodules
- Ulcers
- Tropical pyoderma
- Leishmaniasis
- Mycobacterium marinum
- Buruli ulcer
- Dracunculiasis (Guinea Worm disease)
- Linear and Migratory Lesions
- Cutaneous larvae migrans
- Photodermatitis
See also domestic U.S. ectoparasites
Evaluation
- Blood smear to identify parasite
- Parasites can also be found in lymph nodes, chancres, bone marrow, or CSF
Management
- Consult ID early!
- No CNS involvement
- Pentamidine or suramin
- CNS involvement
- Melarsoprol, eflornithine, or a combination of nifurtimox and eflornithine