Prednisolone: Difference between revisions
| Line 23: | Line 23: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*adrenal insufficiency | |||
*Cushing syndrome | |||
*immunosuppression | |||
*infection | |||
*HTN | |||
*CHF | |||
*diabetes mellitus | |||
*steroid psychosis | |||
*GI perforation/ulcer | |||
*osteopenia/osteoporosis | |||
*hypokalemic alkalosis | |||
*steroid myopathy | |||
*tendon rupture | |||
*pseudotumor cerebri | |||
*ICP incr. | |||
*seizures | |||
*glaucoma | |||
*cataracts | |||
*pancreatitis | |||
*growth suppression (long-term use, peds pts) | |||
*exophthalmos | |||
*anaphylaxis | |||
*withdrawal sx if abrupt D/C (high dose or long-term use) | |||
===Common=== | ===Common=== | ||
Revision as of 21:43, 29 June 2015
General
- Type: Corticosteroid
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Probably Safe
- Renal Dosing
- Adult: no adjustment
- Pediatric: no adjustment
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- adrenal insufficiency
- Cushing syndrome
- immunosuppression
- infection
- HTN
- CHF
- diabetes mellitus
- steroid psychosis
- GI perforation/ulcer
- osteopenia/osteoporosis
- hypokalemic alkalosis
- steroid myopathy
- tendon rupture
- pseudotumor cerebri
- ICP incr.
- seizures
- glaucoma
- cataracts
- pancreatitis
- growth suppression (long-term use, peds pts)
- exophthalmos
- anaphylaxis
- withdrawal sx if abrupt D/C (high dose or long-term use)
Common
Pharmacology
- Half-life: 18-36h
- Metabolism: liver, CYP450: 3A4 substrate
- Excretion: urine
- Mechanism of Action: exact mechanism of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects