Clozapine: Difference between revisions
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**Diabetes | **Diabetes | ||
**Decreased seizure threshold | **Decreased seizure threshold | ||
*"Other adverse cardiovascular and respiratory effects" <ref>"Clozaril (Clozapine) drug description - FDA approved labeling for prescription drugs and medications at RxList". Rxlist.com. Retrieved 2008-10-09.</ref> | *"Other adverse cardiovascular and respiratory effects" <ref name="FDA">"Clozaril (Clozapine) drug description - FDA approved labeling for prescription drugs and medications at RxList". Rxlist.com. Retrieved 2008-10-09.</ref> | ||
*"Increased mortality in elderly patients with dementia-related psychosis"<ref | *"Increased mortality in elderly patients with dementia-related psychosis"<ref name="FDA" /> | ||
==Pharmacology== | ==Pharmacology== | ||
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==Sources== | ==Sources== | ||
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*Lange Poisoning and Drug Overdose, 6th Ed., p. 443-4, 160-162 | *Lange Poisoning and Drug Overdose, 6th Ed., p. 443-4, 160-162 | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:Psych]] | [[Category:Psych]] |
Revision as of 08:45, 10 August 2015
General
- Type: Atypical antipsychotic
- Dosage Forms:
- Common Trade Names:
Adult Dosing
- Controls positive and negative symptoms of psychotic disorders
- Used for schizophrenia
- Off label use:
- Bipolar disorder
- Borderline personality disorder
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- QT prolongation
- Myocarditis
- Agranulocytosis in 1%–2% of patients during initial treatment 3 months
- Highest ~3 months into treatment and then decreases
- Other potential side effects:
- Dyslipidemia
- Diabetes
- Decreased seizure threshold
- "Other adverse cardiovascular and respiratory effects" [1]
- "Increased mortality in elderly patients with dementia-related psychosis"[1]
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
See Also
Sources
- Lange Poisoning and Drug Overdose, 6th Ed., p. 443-4, 160-162