Hemostatic agents

Active Agents

Plant-Based	Oxidized cellulose (OC) and oxidized regenerated cellulose (ORC)
Gelatin-based	Purified pork or bovine skin; absorbs 45 times its weight of its initial volume causing hemostasis. Excessive swelling can lead to nerve compression
Collagen-based	Derived from tissue; shows cell compatibility, adhesion, growth and migration.
Fibrin-based	High concentrations of fibrinogen, thrombin and additional components (clotting factors)
Thrombin-based	Directly participate in the coagulation cascade process that promotes and modulates coagulation. Provides a lattice for platelet aggregation and thrombus formation.
Chitin-based	Polysaccharide biopolymer produced naturally by algae through fermentation. Also known as chitosan in its deacetylated form. Chitosan has been shown to be more effective that chitin in controlling severe hemorrhage.

Use

• For compressible hemorrhage not amenable to tourniquet use or as an adjunct to tourniquet removal (if evacuation time is anticipated to be longer than two hours), use Combat Gauze
• Celox Gauze and ChitoGauze may also be used if Combat Gauze is not available.
• Hemostatic dressings should be applied with at least 3 minutes of direct pressure.

See Also

• Bleeding treatments
• Tactical combat casualty care