Clozapine

General

• Type: Atypical antipsychotic
• Dosage Forms:
  • 12.5, 25, 50, 100, 200
  • 12.5, 25, 50, 100, 150, 200 ODT
• Common Trade Names: Clozaril, FezaClo, Versacloz

Special Populations

• Pregnancy Rating:
• Lactation:
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Indications

• Controls positive and negative symptoms of psychotic disorders
• Used for schizophrenia
• Off label use:
  • Bipolar disorder
  • Borderline personality disorder

Contraindications

• Allergy to class/drug

Adverse Reactions

• QT prolongation
• Myocarditis
• Agranulocytosis in 1%–2% of patients during initial treatment 3 months
  • Highest ~3 months into treatment and then decreases
• Other potential side effects:
  • Dyslipidemia
  • Diabetes
  • Decreased seizure threshold
• "Other adverse cardiovascular and respiratory effects"
• "Increased mortality in elderly patients with dementia-related psychosis"

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

See Also

• Schizophrenia
• Bipolar disorder
• Borderline personality disorder
• Antipsychotic Medications