Disulfiram effect

Background

The disulfiram effect refers to medication adverse effect that are similar to those seen with disulfiram (trade names Antabuse, Antabus). Disulfiram is a drug that is used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol. Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, which means many of the effects of a "hangover" are felt immediately after alcohol is consumed. The disulfiram effect refers to similar symptoms seen when other medications are mixed with ethanol.

Medications with Similar Effects

• Antibiotics (metronidazole, cephalosporins (cefotetan))
• Antifungals (Griseofulvin)

Treatment

Care is primarily supportive.