Template:PCP pneumonia antibiotics

Mild Disease

• TMP/SMX 2 DS tablets PO q8hrs OR
  • High incidence of allergy in HIV
• Dapsone 100mg PO once daily + TMP 5mg/kg PO q8hrs OR
  • caution: dapsone can cause methemoglobinemia
• Atavaquone 750mg PO q12hrs OR
• Primaquine 30mg PO q24hrs + Clindamycin 450mg PO q8hrs

Severe Disease

• TMP/SMX 5mg/kg IV q8hrs x 21 days OR
• Pentamidine 4mg/kg IV daily over 60 min OR
  • Watch for side effects of hypoglycemia and hypotension
• Primaquine 30mg PO once daily + Clindamycin 900mg IV q8hrs

Prophylaxis

• TMP/SMX 1 DS tablet daily, but one single strength tablet daily or one double-strength three times weekly is acceptable.

Pediatric Treatment

• TMP/SMX 5mg/kg (TMP) IV/PO q6-8hrs x 21 days
• Pentamidine 4mg/kg IV daily x 21 days if TMP/SMX intolerant
• Dapsone 2mg/kg/day PO (max 100mg) + TMP 15mg/kg/day PO divided TID for mild disease

Pediatric Prophylaxis

• TMP/SMX 5mg/kg/day (TMP) PO divided BID 3 days/week (first line)
• Dapsone 2mg/kg/day PO daily (max 100mg) or Atovaquone as alternatives