Sulfadiazine
Administration
- Type: Antibiotic
- Dosage Forms: Tablet, 500mg
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Toxoplasmosis | 1g PO q6hrs | Immunocompetent with Pyrimethamine |
| Toxoplasmosis | 1500mg PO q6hrs | Immunosuppressed with Pyrimethamine |
Pediatric Dosing
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Toxoplasmosis | 50mg/kg PO BID | Congenital/Pediatric |
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk has been demonstrated
- Renal dosing: use with caution
- Hepatic dosing: use with caution
Contraindications
- Allergy to class/drug
- Infants <2mo (except to treat congenital toxoplasmosis)
- Pregnant women at term
- Breastfeeding
Adverse Reactions
Serious
- SJS/TEN
- Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, aplastic anemia
- Crystalluria
- Allergic Myocarditis
Common
- Rash
- Nausea/vomiting, diarrhea, abdominal pain
- Tinnitus
- Headache, Depression, Insomnia
Pharmacology
- Half-life: 7-16.8h
- Metabolism: Hepatic
- Excretion: Mostly renal
Mechanism of Action
- Inhibits bacterial synthesis of folic acid