Ibutilide

Adult Dosing

• Loading dose = 1mg IV in 50mL D5W over 10min (wt>60kg)
• Loading dose = 0.01mg/kg IV in 50mL D5W over 10min (wt<60kg)
• Dose may be repeated 10min after completion of 1st dose

Indications

• Rapid conversion of recent-onset A-fib/flutter to NSR

Mechanism of Action

• Class III - Prolongs AP and refractory period

Adverse Drug Rxns

• QT prolongation, V-tach, torsades
• Observe for 4hr after infusion

Kinetics

• Onset of action = 20-30min
• Duration of action = 24hr

See Also

Antiarrhythmics