Aplastic anemia: Difference between revisions
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==Diagnosis== | ==Diagnosis== | ||
*CBC: pancytopenia | |||
*Reticulocyte count: reduced or absent | |||
*Peripheral smear | |||
==Management== | ==Management== | ||
Revision as of 00:05, 11 July 2016
Background
- absence or decrease number of hematopoietic precursor cells --> pancytopenia (anemia, thrombocytopenia, neutropenia)
- causes
- drug-induced (chloramphenicol, carbamazepine, valproic acid, phenytoin)
- viral infection (parvovirus B19, HIV, hepatitis), especially in patients w/ sickle cell disease or immunocompromise
- autoimmune
- congenital (Fanconi anemia)
Clinical Features
- anemia
- weakness, fatigue, dyspnea
- thrombocytopenia
- mucosal bleeding, petechiae
- neutropenia
- recurrent infections, fever
Differential Diagnosis
Diagnosis
- CBC: pancytopenia
- Reticulocyte count: reduced or absent
- Peripheral smear