Gyromitra mushrooms: Difference between revisions
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==Background== | |||
[[File:Gyromitra_mushrooms.jpg|thumb|Gyromitra mushrooms]] | [[File:Gyromitra_mushrooms.jpg|thumb|Gyromitra mushrooms]] | ||
*Also known as "brain fungi" | *Also known as "brain fungi" | ||
*Fruit in the spring and early summer | *Fruit in the spring and early summer | ||
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*Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite | *Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite | ||
==Clinical | ==Clinical Features== | ||
*GI upset, fatigue, muscle cramps | *GI upset, fatigue, muscle cramps | ||
*Liver failure | *[[Liver failure]] | ||
*Hypoglycemia | *[[Hypoglycemia]] | ||
*Rhabdomyolysis | *[[Rhabdomyolysis]] | ||
*Can present with refractory seizures due to GABA deficiency | *Can present with refractory seizures due to GABA deficiency | ||
*Hemolysis usually mild | *Hemolysis usually mild | ||
*Rarely methemoglobinemia | *Rarely methemoglobinemia | ||
==Workup<ref>Tomková J, Ondra P, Válka I. Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. Forensic Sci Int. 2015 Jun. 251:209-13.</ref>== | ==Differential Diagnosis== | ||
{{Mushroom toxicity DDX}} | |||
==Diagnosis== | |||
===Workup<ref>Tomková J, Ondra P, Válka I. Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. Forensic Sci Int. 2015 Jun. 251:209-13.</ref>=== | |||
*Blood sugar | *Blood sugar | ||
*BMP | *BMP | ||
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*Folinic acid supplementation (hydrazines inhibit MTHF production) | *Folinic acid supplementation (hydrazines inhibit MTHF production) | ||
*Liver transplant for refractory hepatic failure | *Liver transplant for refractory hepatic failure | ||
==Disposition== | |||
==See Also== | ==See Also== | ||
Revision as of 22:09, 11 May 2016
Background
- Also known as "brain fungi"
- Fruit in the spring and early summer
- Frequently mistaken for morel mushrooms[1]
- Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite
Clinical Features
- GI upset, fatigue, muscle cramps
- Liver failure
- Hypoglycemia
- Rhabdomyolysis
- Can present with refractory seizures due to GABA deficiency
- Hemolysis usually mild
- Rarely methemoglobinemia
Differential Diagnosis
Mushroom toxicity by Type
| Mushroom | Toxin | Pathologic Effect |
| Amanita | Amatoxin | Hepatotoxicity |
| Coprine | Disulfiram-like | |
| Crotinarius | Orellanine | Delayed renal failure |
| Gyromitra | Gyromitrin | Seizures |
| Ibotenic Acid | Anticholinergic | |
| Muscarine | Cholinergic | |
| Orellanin | Nephrotoxicity | |
| Psilocybin | Hallucinations |
Diagnosis
Workup[2]
- Blood sugar
- BMP
- LFT
- Coags
- CBC with differential
- LDH, haptoglobin, reticulocyte
- CK
- MetHb level
- Urine drug screen
- Urinalysis
Management[3]
- Supportive care
- Dextrose boluses/infusions
- High dose pyridoxine for refractory seizures (5g IV initially)
- Avoid phenobarbital, especially in liver failure
- Methylene blue for severe methemoglobinemia
- Folinic acid supplementation (hydrazines inhibit MTHF production)
- Liver transplant for refractory hepatic failure
Disposition
See Also
References
- ↑ Brozen R et al. Gyromitra Mushroom Toxicity. Apr 14, 2015. http://emedicine.medscape.com/article/817931-treatment#showall.
- ↑ Tomková J, Ondra P, Válka I. Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. Forensic Sci Int. 2015 Jun. 251:209-13.
- ↑ Diaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36.