Psilocybin

Background

  • A compound found in over 200 mushrooms that has mind altering properties similar to LSD.
  • Commonly known as "magic mushrooms" or "shrooms". The mushroom are often taken recreationally for the euphoric and hallucinogenic effects. Typically grown in the Pacific Northwest and southern regions of the United States.
  • For a typical dose (1mg) symptoms will last 1-3 hours.
  • Low toxicity with LD50 of 280mg/kg
    • Therapeutic index = 641
Psilocybe semilanceata

Clinical Features

Differential Diagnosis

Drugs of abuse

Evaluation

Management

  • Supportive care
  • Place patient in a calm and quiet environment
  • Benzodiazepines for worsening tachycardia/hypertension or agitation

Disposition

  • Discharge when vitals normalize and clinically sober

See Also

References