IV nitroglycerine alternatives: Difference between revisions

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==Suggested Substitutions<ref>http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/45056</ref>==
==Suggested Substitutions<ref>http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/45056</ref>==
#Sublingual nitroglycerin, 1-2 tabs or sprays every 5 minutes as needed
*Sublingual nitroglycerin, 1-2 tabs or sprays every 5 minutes as needed
##Once controlled
**Once controlled
###Nitropursside '''OR''' Isordil PO (nitro paste or longer acting NTG)
***[[Nitropursside]] '''OR''' [[Isordil]] PO (nitro paste or longer acting NTG)
##If not well controlled
**If not well controlled
###IV enalapril 0.625-1.25mg IV bolus
***IV [[enalapril]] 0.625-1.25mg IV bolus
###IV hydralazine 5-10mg IV bolus
***IV [[hydralazine]] 5-10mg IV bolus
###IV nitropursside
***IV [[nitropursside]]


==See Also==
==See Also==

Revision as of 17:50, 3 December 2015

Background

  • Suggestions for substitution during the IV shortage

Nitroglycerine Bioavailability

  • Oral [1]: <1%
  • Sublingual [1]: 38% (15-40%)
  • Topical [1]: 72%

Half-life[2]: 0.05 h

Suggested Substitutions[3]

See Also

References

<references>