CMV retinitis: Difference between revisions
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==Background== | ==Background== | ||
*Most frequent and serious ocular | *Most frequent and serious ocular opportunistic infection | ||
*Leading cause of blindness in AIDS pts | *Leading cause of blindness in AIDS pts | ||
*Typically occurs with CD4 less than 50 | *Typically occurs with CD4 less than 50 | ||
[[File:Fundus photograph-CMV retinitis EDA07.jpg|thumb|Fundus photograph of CMV retinitis]] | [[File:Fundus photograph-CMV retinitis EDA07.jpg|thumb|Fundus photograph of CMV retinitis]] | ||
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==Clinical Features== | |||
*Variable, but may include: | |||
**Change in visual acuity | **Change in visual acuity | ||
**Visual field cuts (Scotomas, loss of central vision) | **Visual field cuts (Scotomas, loss of central vision) | ||
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{{HIV associated conditions}} | {{HIV associated conditions}} | ||
== | ==Diagnosis== | ||
==Management== | |||
===Antivirals=== | ===Antivirals=== | ||
{{CMV retinitis treatment}} | {{CMV retinitis treatment}} | ||
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**Possible cause - T-cell mediated immune reconstitution to latent CMV intraocular antigens | **Possible cause - T-cell mediated immune reconstitution to latent CMV intraocular antigens | ||
**Symptoms - Floaters, photophobia, blurred vision | **Symptoms - Floaters, photophobia, blurred vision | ||
**Occurs median 20 weeks after starting | **Occurs median 20 weeks after starting HAART | ||
**Urgent ophtho eval | **Urgent ophtho eval | ||
==Disposition== | |||
* | |||
==See Also== | ==See Also== | ||
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*[[Cytomegalovirus (CMV) infection]] | *[[Cytomegalovirus (CMV) infection]] | ||
== | ==References== | ||
<References/> | |||
[[Category:ID]] | [[Category:ID]] | ||
[[Category:Ophtho]] | [[Category:Ophtho]] | ||
Revision as of 07:37, 18 August 2015
Background
- Most frequent and serious ocular opportunistic infection
- Leading cause of blindness in AIDS pts
- Typically occurs with CD4 less than 50
Clinical Features
- Variable, but may include:
- Change in visual acuity
- Visual field cuts (Scotomas, loss of central vision)
- Floaters, flashing lights
- Photophobia
- Eye redness/pain
Differential Diagnosis
Acute onset flashers and floaters
- Ocular causes
- Floaters and/or flashes
- Posterior vitreous detachment
- Retinal tear or retinal detachment
- Posterior uveitis
- Predominantly floaters
- Vitreous hemorrhage secondary to proliferative retinopathy
- Sympathetic ophthalmia
- Predominantly flashes
- Oculodigital stimulation
- Rapid eye movements
- Neovascular age-related macular degeneration
- Floaters and/or flashes
- Non-ocular causes
- Intraocular foreign body
- Migraine aura (classic)
- Migraine aura (acephalgicmigraine)
- Occipital lobe disorders
- Postural hypotension
HIV associated conditions
- HIV neurologic complications
- HIV pulmonary complications
- Ophthalmologic complications
- Other
- HAART medication side effects[1]
- HAART-induced lactic acidosis
- Neuropyschiatric effects
- Hepatic toxicity
- Renal toxicity
- Steven-Johnson's
- Cytopenias
- GI symptoms
- Endocrine abnormalities
Diagnosis
Management
Antivirals
Severe Vision Threatening
- Ganciclovir intraocular implant for 8 months AND
- Valganciclovir 900mg PO q12hrs x 14 days FOLLOWED BY 900mg PO q24hrs x 7 days
Peripheral lesions
- Valganciclovir 900mg PO q12hrs x 21 days FOLLOWED BY 900mg PO q24hrs x 7 days
Complications
- Retinal detachment
- Complete Vision loss
- CMV Immune Recovery Uveitis (IRU)
- Patients with retinitis who develop blurry vision after starting HART need ophtho eval to assess for CMV progression, relapse, or IRU
- Possible cause - T-cell mediated immune reconstitution to latent CMV intraocular antigens
- Symptoms - Floaters, photophobia, blurred vision
- Occurs median 20 weeks after starting HAART
- Urgent ophtho eval
Disposition
See Also
References
- ↑ Gutteridge, David L MD, MPH, Egan, Daniel J. MD. The HIV-Infected Adult Patient in The Emergency Department: The Changing Landscape of the Disease. Emergency Medicine Practice: An Evidence-Based Approach to Emergency Medicine. Vol 18, Num 2. Feb 2016.