Template:Sedative agents: Difference between revisions

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===[[Ketamine]]===
===[[Ketamine]]===


===Ketofol===
===[[Ketofol]]===
* 2 definitions
**1. 50% ketamine mixed with 50% propofol in same syringe
**2. Pretreatment with 1/2 dose ketamine, followed by propofol
*Ketamine comes in a 50 mg/mL concentration
*take a 10 mL saline flush and empty 2 mL and draw up 2 mL of ketamine
**100 mg of ketamine in flush
<br>
*Propofol comes in a standard 10 mg/mL concentration.
*fill a different 10 mL syringe with this you have 100 mg of propofol
 
*If you mix the two in a new 20 or 30 mL syringe you get 100 mg ketamine + 100 mg propofol = 200 mg total.
*Every one mL has 10 mg of ketofol.
*Your starting dose of this will be 0.5 mg/kg followed by another 0.5 mg/kg after about 30-60 sec.
*From then on for maintenance you can use 0.25 mg/kg as needed.


===Brevital===
===Brevital===

Revision as of 18:29, 18 June 2015

Sedative agents

Fentanyl/Versed

  • Designed for moderate sedation
    • If titrate to deep sedation, when painful stimulus stops may become apneic
  • Duration = 30min

Etomidate/Fentanyl

  • Similar to versed/fentanyl but better b/c of shorter duration of action
  • Good for brief sedation if don't have access to propofol
    • E.g. shoulder/hip reduction, cardioversion
  • Dose fentanyl first: 0.5-1mcg/kg
  • Etomidate 0.15mg/kg (8-10mg avg)
    • Wears off in 6min

Propofol

Ketamine

Ketofol

Brevital

  • Dose 1-1.5 mg/kg
  • Onset < 1 minute; Duration 10 minutes
  • No analgesic effect
  • Beware of laryngospasm (3 syringe method)

Dexmedetomidine

Brand Name: Precedex[1]

  • Dose 0.5 - 1 mcg/kg initial bolus
  • Infusion 0.2mcg - 0.6mcg/kg for procedure
  • Provides analgesia and anesthesia
  • Hemodynamically neutral medication
  • Apnea risk as with propofol