Ketofol

General

Adult Dosing

  • Starting dose: 0.5mg/kg followed by another 0.5mg/kg after 30-60 seconds
  • Maintenance: 0.25mg/kg as needed

Pediatric Dosing

Special Populations

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

Preparation and Administration

  • Ketamine
    • Comes in a 50mg/mL concentration
    • take a 10 mL saline flush and empty 2 mL and draw up 2 mL of ketamine
      • 100mg of ketamine in flush
  • Propofol
    • Comes in a standard 10mg/mL concentration.
      • fill a different 10 mL syringe with this you have 100mg of propofol
  • If you mix the two in a new 20 or 30 mL syringe you get 100mg ketamine + 100mg propofol = 200mg total.
    • Every one mL has 10mg of ketofol

Comments

  • 2 definitions
    • 50% ketamine mixed with 50% propofol in same syringe
    • Pretreatment with 1/2 dose ketamine, followed by propofol

See Also

References