Fluconazole: Difference between revisions

Revision as of 01:52, 20 March 2026

Disease	Dose	Context
Acute necrotizing ulcerative gingivitis	200mg PO daily x 14 days	Immunocompromised
Candida vulvovaginitis	150mg PO once	Preferred; a second dose at 72hrs may be given if still symptomatic
Candida vulvovaginitis	150mg PO q72h x 3 doses	Severe or immunosuppressed
Candida vulvovaginitis	150mg PO qweek x 6 months	Recurrent; long-term suppressive therapy
Cryptococcosis	400mg PO/IV q24hrs x 6-12 months	Pulmonary not AIDS associated
Cryptococcosis	400mg PO q24hrs x 6-12 months	Pulmonary with AIDS
Cryptococcosis	400mg PO q24hrs x 8 weeks	Meningitis consolidation not AIDS
Cryptococcosis	400mg PO q24hrs x 8 weeks	Meningitis consolidation with AIDS
Oropharyngeal candidiasis	200 mg PO on day one, followed by 100 mg daily for two weeks	Adult

Disease	Dose	Context
Cryptococcosis	6-12mg/kg PO daily x 8 weeks (max 400mg)	Pediatric Consolidation
Oropharyngeal candidiasis	6 mg/kg PO on day one, followed by 3 mg/kg daily for two weeks	Pediatric
Tinea capitis	6mg/kg PO daily (max 400mg) x 3-6 weeks	Second line

Pregnancy Rating: D
Lactation Risk Categories: safety unknown
Renal Dosing
- Adult:CrCrl < 50, give usual loading dose x 1 then decrease dose 50%
- Pediatric: CrCrl < 50, give usual loading dose x 1 then decrease dose 50%
Hepatic Dosing
- Adult: not defined
- Pediatric: not defined

Half-life: 30 hour
Metabolism: Liver
Excretion: urine
Mechanism of Action: inhibits cytochrome P450 and sterol c-14 alpha-demethylation

@@ Line 5: / Line 5: @@
 ==Adult Dosing==
-===General===
+===Indications by Disease===
-[[Candidiasis]], oropharyngeal/esophageal
+{{#ask: [[Has DrugName::Fluconazole]] [[Has Population::Adult]]
-*100mg PO qday x 2 week to prevent relapse
+|?Treats disease=Disease
+|?Has Dose=Dose
-[[Candida vaginitis]]
+|?Has Context=Context
-*Uncomplicated: 150mg PO x 1
+|format=table
+|limit=50
+|mainlabel=-
+|headers=show
+|sort=Treats disease
+}}
 ==Pediatric Dosing==
-Candidiasis, oropharyngeal/esophageal:
+===Indications by Disease===
-*> 14 days old: 6mg/kg PO x 1, then 3mg/kg q24h x 7-14 days, max: 100mg/day
+{{#ask: [[Has DrugName::Fluconazole]] [[Has Population::Pediatric]]
+|?Treats disease=Disease
-Tinea Capitis:
+|?Has Dose=Dose
-> 14 days old: 3-6mg/kg PO q24h x 6 weeks
+|?Has Context=Context
+|format=table
+|limit=50
+|mainlabel=-
+|headers=show
+|sort=Treats disease
+}}
 ==Special Populations==