Template:PCP pneumonia antibiotics: Difference between revisions
(Convert to AntibioticDose with disease=Pneumocystis jirovecii pneumonia for SMW linking) |
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====Mild Disease==== | ====Mild Disease==== | ||
* | *{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Trimethoprim-Sulfamethoxazole DS|dose=2 DS tablets PO q8hrs|context=Mild disease|display=TMP/SMX|population=Adult}} OR | ||
**High incidence of allergy in HIV | **High incidence of allergy in HIV | ||
* | *{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Dapsone|dose=100mg PO once daily|context=Mild disease with TMP|population=Adult}} + [[Trimethoprim-Sulfamethoxazole DS|TMP]] 5mg/kg PO q8hrs OR | ||
**''caution: dapsone can cause methemoglobinemia'' | **''caution: dapsone can cause methemoglobinemia'' | ||
*[[Atavaquone]] 750mg PO q12hrs OR | *[[Atavaquone]] 750mg PO q12hrs OR | ||
* | *{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Primaquine|dose=30mg PO q24hrs|context=Mild disease with Clindamycin|population=Adult}} + {{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Clindamycin|dose=450mg PO q8hrs|context=Mild disease with Primaquine|population=Adult}} | ||
====Severe Disease==== | ====Severe Disease==== | ||
* | *{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Trimethoprim-Sulfamethoxazole DS|dose=5mg/kg IV q8hrs x 21 days|context=Severe disease|display=TMP/SMX|population=Adult}} OR | ||
* | *{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Pentamidine|dose=4mg/kg IV daily over 60 min|context=Severe disease|population=Adult}} OR | ||
**Watch for side effects of hypoglycemia and hypotension | **Watch for side effects of hypoglycemia and hypotension | ||
* | *{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Primaquine|dose=30mg PO once daily|context=Severe disease with Clindamycin|population=Adult}} + {{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Clindamycin|dose=900mg IV q8hrs|context=Severe disease with Primaquine|population=Adult}} | ||
====Prophylaxis==== | ====Prophylaxis==== | ||
* | *{{AntibioticDose|disease=Pneumocystis jirovecii pneumonia|drug=Trimethoprim-Sulfamethoxazole DS|dose=1 DS tablet daily|context=Prophylaxis|display=TMP/SMX|population=Adult}}, but one single strength tablet daily or one double-strength three times weekly is acceptable.<ref>CDC Guidelines for Prophylaxis Against Pneumocystis carinii Pneumonia for Children Infected with Human Immunodeficiency Virus http://www.cdc.gov/mmwr/preview/mmwrhtml/00001957.htm</ref> | ||
Revision as of 01:30, 20 March 2026
Mild Disease
- TMP/SMX 2 DS tablets PO q8hrs OR
- High incidence of allergy in HIV
- Dapsone 100mg PO once daily + TMP 5mg/kg PO q8hrs OR
- caution: dapsone can cause methemoglobinemia
- Atavaquone 750mg PO q12hrs OR
- Primaquine 30mg PO q24hrs + Clindamycin 450mg PO q8hrs
Severe Disease
- TMP/SMX 5mg/kg IV q8hrs x 21 days OR
- Pentamidine 4mg/kg IV daily over 60 min OR
- Watch for side effects of hypoglycemia and hypotension
- Primaquine 30mg PO once daily + Clindamycin 900mg IV q8hrs
Prophylaxis
- TMP/SMX 1 DS tablet daily, but one single strength tablet daily or one double-strength three times weekly is acceptable.[1]
- ↑ CDC Guidelines for Prophylaxis Against Pneumocystis carinii Pneumonia for Children Infected with Human Immunodeficiency Virus http://www.cdc.gov/mmwr/preview/mmwrhtml/00001957.htm