Hyperamylasemia: Difference between revisions
| Line 17: | Line 17: | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
*Pancreatic: | *Pancreatic: | ||
* * Acute pancreatitis | ** Acute pancreatitis | ||
* * | ** | ||
* * [[Chronic pancreatitis]] (can have normal or mildly elevated levels) | ** [[Chronic pancreatitis]] (can have normal or mildly elevated levels) | ||
* * | ** | ||
* * Pancreatic pseudocyst | ** Pancreatic pseudocyst | ||
* * | ** | ||
* * Pancreatic duct obstruction | ** Pancreatic duct obstruction | ||
* * | ** | ||
* * Pancreatic trauma or neoplasm | ** Pancreatic trauma or neoplasm | ||
* * | ** | ||
* Non-Pancreatic: | * Non-Pancreatic: | ||
* * Salivary gland disease (e.g., [[Parotitis|parotitis]]) | ** Salivary gland disease (e.g., [[Parotitis|parotitis]]) | ||
* * | ** | ||
* * Perforated peptic ulcer | ** Perforated peptic ulcer | ||
* * | ** | ||
* * [[Bowel obstruction]] or infarction | ** [[Bowel obstruction]] or infarction | ||
* * | ** | ||
* * [[Cholecystitis]] | ** [[Cholecystitis]] | ||
* * | ** | ||
* * [[Ectopic pregnancy]] | ** [[Ectopic pregnancy]] | ||
* * | ** | ||
* * Ruptured aortic aneurysm | ** Ruptured aortic aneurysm | ||
* * | ** | ||
* * Macroamylasemia | ** Macroamylasemia | ||
* * | ** | ||
* * Renal failure (impaired clearance) | ** Renal failure (impaired clearance) | ||
==Evaluation== | ==Evaluation== | ||
Revision as of 18:46, 5 May 2025
Background
- Amylase is secreted by the pancreas into the duodenum where it aids the catabolism of carbohydrates to simple sugars[1]
- Damage to the pancreas or obstruction to the pancreatic duct causes the enzyme to enter the bloodstream.
Clinical Features
- Pain in the middle of the chest that radiates to the back
- Fever
- Loss of appetite
- Nausea
- Vomiting
- Sweating
- Weakness
- Jaundice
- Rapid pulse
- Steatorrhea
Differential Diagnosis
- Pancreatic:
- Acute pancreatitis
- Chronic pancreatitis (can have normal or mildly elevated levels)
- Pancreatic pseudocyst
- Pancreatic duct obstruction
- Pancreatic trauma or neoplasm
- Non-Pancreatic:
- Salivary gland disease (e.g., parotitis)
- Perforated peptic ulcer
- Bowel obstruction or infarction
- Cholecystitis
- Ectopic pregnancy
- Ruptured aortic aneurysm
- Macroamylasemia
- Renal failure (impaired clearance)
Evaluation
Workup
Diagnosis
- Amylase level >100 U/dl
Management
Disposition
See Also
External Links
References
- ↑ Concise Book of Medical Laboratory Technology: Methods and Interpretations. 2nd Edition. 2015. Ramnik Sood. ISBN: 978-93-5152-333-8. Pag. 519.